Design, setting, and participants randomized, doubleblind, placebocontrolled study measuring effects on intimamedia thickness. Is ezetimibesimvastatin no better than simvastatin alone. Data on file, 267039, astrazeneca pharmaceuticals lp. Statins and crp in addition to its ldlclowering effects, statin treatment reduces the level of creactive. Aurora was a randomized, doubleblind, placebocontrolled, multicenter trial. Request pdf creactive protein lowering with rosuvastatin in the meteor study. Rosuvastatin also demonstrated antioxidant effects and beneficial effects on endothelial function and platelets. In short meteor was a 2year, doubleblind, placebocontrolled trial that compared rosuvastatin 40 mg with placebo treatment in middleaged asymptomatic subjects with moderately elevated cholesterol and low risk of cardiovascular disease according to the national cholesterol educational. Reduction in creactive protein and ldl cholesterol and cardiovascular event rates after initiation of rosuvastatin. The present study was a post hoc analysis from the meteor trial that was designed and powered to assess the effect of rosuvastatin on rate of change in cimt during 2 years of treatment in lowrisk individuals with increases in cimt. Yet, our present findings suggest that six months of rosuvastatin 20 mg therapy yields no change in mean ccimt in scleroderma patients. Comparative effectiveness of rosuvastatin versus other. Crestor rosuvastatin calcium tablets prescribing information. Impact of statin therapy on the artery wall in the lowrisk.
It comes in the form of a tablet you take by mouth. Crestor clinical trials and studies crestor rosuvastatin. Myalgia was the most common adverse reaction that led to treatment discontinuation. In the meteor study, involving 981 participants treated with rosuvastatin 40 mg n700 or placebo n281 with a mean treatment duration of 1. Rosuvastatin is a highly efficacious statin, and the measuring effects on intima media thickness. Data from the measuring effects on intimamedia thickness. Randomized, doubleblind, placebocontrolled study measuring effects on intimamedia thickness. Listing a study does not mean it has been evaluated by the u. Rosuvastatin improves impaired endothelial function. Rosuvastatin and atorvastatin equally regress atherosclerosis.
Ultrasound images from the far walls of the left and right common carotid arteries were used for evaluation of the echolucency of the carotid intimamedia, measured by grayscale median gsm. Cabozantinib versus everolimus in advanced renal cell. For the heterozygous type, rosuvastatin can be used in children who are at least 8 years old. Meteor, 2007 trial summary pdf trial summary a randomised clinical trial investigating the effect of rosuvastatin versus placebo in individuals, with either age mean, 57 years as the only coronary heart disease risk factor or a 10year framingham risk score of less than 10%, modest cimt thickening 1. In the meteor study, 40 mg rosuvastatin resulted in a significant reduction in the rate of progression of maximum ccimt values over two years in middleaged patients with subclinical atherosclerosis. A study measuring effects on intima media thickness. Patients with unexplained persistent proteinuria andor hematuria during routine urinalysis testing should be instructed to reduce the dose of rosuvastatin according to clinical standards. Intensive lipid lowering may reduce progression of carotid.
An association between rosuvastatin and the development of proteinuria and microscopic hematuria was observed among treated patients during clinical trials. Comparison of effects on lowdensity lipoprotein cholesterol and highdensity lipoprotein cholesterol with rosuvastatin versus atorvastatin in patients with type iia or iib hypercholesterolemia. Heart outcomes prevention evaluation3 full text view. Effect of rosuvastatin on progression of carotid intimamedia. Launched in 2008, the saturn study is a randomized, doubleblind clinical trial designed to test the effectiveness of the maximum doses of rosuvastatin and atorvastatin to regress coronary.
Although the study was not powered for a direct comparison between the two statins, results of both planet i and ii suggest that atorvastatin and rosuvastatin have different renal profiles in patients with proteinuria, whereas the effects on lipids are similar, with a larger effect of rosuvastatin 40 mg than of atorvastatin 80 mg. A higher percentage of rosuvastatin treated patients vs placebotreated patients 6. Effect of rosuvastatin on carotid intimamedia thickness. Clinical experience crestor rosuvastatin calcium for. Effect of rosuvastatin on progression of carotid intimamedia thickness in lowrisk individuals with subclinical atherosclerosis. The randomised phase 3 meteor trial compared the efficacy and safety of cabozantinib versus the mtor inhibitor everolimus in patients with advanced renal cell carcinoma who progressed after previous vegfr tyrosinekinase inhibitor treatment.
Rosuvastatin is available as the brandname drug crestor. Comparative effectiveness of rosuvastatin versus other statins 5 reductions 1 to 4. Rosuvastatin is a statin with antilipidemic and potential antineoplastic activities. Effect of rosuvastatin on progression of carotid intima. Study d3562c00088 meteor demonstrates an improvement in cimt with rosuvastatin 40 mg per day in comparison with placebo. Effect of rosuvastatin on the echolucency of the common. Rosuvastatin improves impaired endothelial function, lowers. This leads to a decrease in hepatic cholesterol levels and increase in uptake of ldl. Following a 4week runin phase with active treatment in all eligible patients, 12,705 patients were randomized in a 2 x 2 factorial design to either all randomizations were done in a 1. Rosuvastatin and cardiovascular events in patients. Dailymed crestor rosuvastatin calcium tablet, film coated. Important safety information from the jupiter study. Creactive protein lowering with rosuvastatin in the. An evaluation of rosuvastatin in subclinical atherosclerosisthe rationale and methodology of the meteor study john robert crouse iii1, diederick e.
Meteor supports statin treatment in lowrisk patients. For the homozygous type, rosuvastatin can be used in. Creactive protein lowering with rosuvastatin in the meteor. The meteor study included men aged 45 to 70 years and women aged 66 to 70 years with an ldlc of either 3. Results among participants in the rosuvastatin group, the mean sd baseline ldl cholesterol level of 155 24. Renal effects of atorvastatin and rosuvastatin in patients. Sep 26, 2005 a study measuring effects on intima media thickness.
Primary prevention of atherosclerotic cardiovascular disease. Rate of change of maximum imt at 12 carotid sites rosuvastatin vs placebo time years 0. Results are available from three trials meteor, orion, and asteroid examining the effect of rosuvastatin on atherosclerosis. An evaluation of rosuvastatin 40 mg meteor the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. In a clinical study, administration of a single dose of rosuvastatin with eltrombopag increased plasma rosuvastatin auc by 55% and the cmax by 103%. Effect of rosuvastatin on carotid intimamedia thickness in. Ldl c was higher and elevated hscrp was not an inclusion criterion. It is a shame that the asteroid and meteor studies involving crestor, which were also imaging studies. Rosuvastatin, sold under the trade name crestor among others, is a statin medication, used to prevent cardiovascular disease in those at high risk and treat abnormal lipids. Creactive protein lowering with rosuvastatin in the meteor study. May 03, 2007 heart outcomes prevention evaluation3 hope3 the safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
It is recommended to be used together with dietary changes, exercise, and weight loss. Common side effects include abdominal pain, nausea, headaches, and muscle pains. Nov 09, 2018 in the meteor study, involving 981 participants treated with rosuvastatin 40 mg n700 or placebo n281 with a mean treatment duration of 1. In the meteor study, involving 981 participants treated with rosuvastatin 40 mg n 700 or placebo n 281 with a mean treatment duration of 1. Rosuvastatin and cardiovascular events in patients undergoing. Crestor rosuvastatin calcium dose, indications, adverse. Heart outcomes prevention evaluation3 american college of. In addition, the dose of rosuvastatin was higher in the meteor study compared to the jupiter.
Request pdf on jun 1, 2009, m bots and others published creactive protein lowering with rosuvastatin in the meteor study find, read and cite all the research you need on researchgate. Cabozantinib is an oral inhibitor of tyrosine kinases including met, vegfr, and axl. A higher percentage of rosuvastatintreated patients vs placebotreated patients 6. However, meteor included a different group of patients to jupiter. Rosuvastatin is a commonly used cholesterol lowering agent statin that is associated with mild, asymptomatic and selflimited serum aminotransferase elevations during therapy, and rarely with clinically apparent acute liver injury. Rosuvastatin is also used to treat hereditary types of high cholesterol hypercholesterolemia. Jan 18, 2017 the measuring effects on intimamedia thickness. Heart outcomes prevention evaluation3 hope3 the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Meteor was a randomized, doubleblind, placebocontrolled, multicenter, 2year, primary prevention trial.
1189 556 1004 1276 1483 760 285 1584 1154 1400 149 1182 1440 934 619 795 100 1144 1169 1276 945 468 111 563 1216 263 165 954 1031 67 778